CCR Podcast 3 - Shay McGuinness on PEPTIC
PEPTIC is a large, multi-centre, cluster cross over, randomised registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients
It will provide robust estimates of the relative risk of stress-related upper gastrointestinal (GI) bleeding and complications that are potentially related to using PPIs vs. H2RBs for stress ulcer prophylaxis. During the first treatment period, half of the participating ICUs will be randomly assigned to use PPIs for stress ulcer prophylaxis in patients who require life-support while the other half will use H2RBs. During the second treatment period each ICU will swap to using the opposite treatment. Data will be collected primarily from existing data sources rather than the medical records of individual patients. There will be two study treatment periods.
The primary outcomes are:
- stress-related upper GI bleeds proven by upper GI endoscopy,
- clostridium difficile infections
- episodes of mechanical ventilation of more than 10 days