The steroid domain of the REMAP-CAP trial was published in JAMA on September 2nd, 2020 and reported a high probability of benefit with hydrocortisone in severe COVID-19. A meta analysis published alongside this trial result confirmed the efficacy of steroids in critically ill patients with COVID-19.

The Irish Critical Care - Clinical Trials Network contributed to this major international trial. Prof Alistair Nichol spoke with Newstalk about the significance of these results.

The results in this report have been produced using data from Ireland using the ISARIC COVID-19 database. Up to the date of this report, data have been entered for 501 individuals. The analysis detailed in this report only includes individuals for whom data collection commenced on or before 02 July 2020.

The cohort comprises 493 individuals, including 310 males and 180 females – sex is unreported for 3 cases. SARS-COV-2 infection has been confirmed by laboratory testing in 304 individuals. 189 individuals are recorded as suspected of SARS-COV-2 infection, without laboratory confirmation at the time of data analysis.The median age is 60 years. The minimum and maximum observed agesare 5 and 103 years respectively. Outcomes have been recorded for 51 patients, consisting of 0 recoveries and 51 deaths. Follow-up is ongoing for 75 patients. Outcome records are unavailable for 59 patients.

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This ISARIC COVID-19 report has been collected from 85,973 individuals from 545 sites across 42 countries. The analysis details 60,439 individuals for whom data collection commenced on or before 29 June 2020 and who have laboratory-confirmed (97.6%) or clinically-diagnosed (2.4%) SARS-COV-2 infection.

Outcomes have been recorded for 51,270 patients, consisting of 34,239 recoveries and 17,031 deaths. Follow-up is ongoing for 3,209 patients. Outcome records are unavailable for 5,969 patients. A total of 9,754 (16%) patients were admitted at some point of their illness into an intensive care unit or high dependency unit. Of these, 3,348 died, 705 are still in hospital and 4,335 have recovered and been discharged.