PUBLICATIONS

 

Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial.

Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group. Trials. 2018 Apr 27;19(1):259. doi: 10.1186/s13063-018-2610-y. PMID:29703266

 

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study.

Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Intensive Care Med. 2018 Apr 9. doi: 10.1007/s00134-018-5152-6. [Epub ahead of print] PMID:29632996

 

Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis.

McQuilten ZK, French CJ, Nichol A, Higgins A, Cooper DJ. Transfus Med Rev. 2018 Apr;32(2):77-88. doi: 10.1016/j.tmrv.2018.02.002. Epub 2018 Feb 17. Review. PMID:29526337

 

Bending the Pandemic Curve: Improving Decision-Making With Clinical Research.

Webb SA, Nichol AD. Crit Care Med. 2018 Mar;46(3):442-446. doi: 10.1097/CCM.0000000000002912. No abstract available. PMID: 29474325

 

The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial.

Cosgrave D, Galligan M, Soukhin E, McMullan V, McGuinness S, Puttappa A, Conlon N, Boylan J, Hussain R, Doran P, Nichol A. Trials. 2017 Dec 29;18(1):633. doi: 10.1186/s13063-017-2370-0. PMID: 29284510

 

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Intensive Care Med. 2018 Jan;44(1):157-165. doi: 10.1007/s00134-017-4981-z. PMID: 29138899

 

Cause and timing of death and sub-group differential effects of erythropoietin in the EPO-TBI study.

Skrifvars MB, French C, Bailey M, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R. J Neurotrauma. 2017 Oct 12. doi: 10.1089/neu.2017.5135. [Epub ahead of print] PMID: 29020866

 

Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries.

Gobat NH, Gal M, Butler CC, Webb SAR, Francis NA, Stanton H, Anthierens S, Bastiaens H, Godycki-Ćwirko M, Kowalczyk A, Pons-Vigués M, Pujol-Ribera E, Berenguera A, Watkins A, Sukumar P, Moore RG, Hood K, Nichol A. Health Expect. 2018 Feb;21(1):387-395. doi: 10.1111/hex.12634. Epub 2017 Sep 27. PMID: 28960624

 

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults.

Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med. 2017 Nov 9;377(19):1858-1867. doi: 10.1056/NEJMoa1707572. Epub 2017 Sep 27. PMID: 28952891

 

Targeted therapeutic mild hypercapnia after cardiac arrest.

Eastwood GM, Nichol A, Wise MP. Crit Care. 2017 Jul 31;21(1):196. doi: 10.1186/s13054-017-1770-6. No abstract available. PMID: 28756765

 

Co-enrolment for the TAME and TTM-2 trials: the cerebral option.

Parke RL, McGuinness S, Eastwood GM, Nichol A, Nielsen N, Dankiewicz J, Bellomo R. Crit Care Resusc. 2017 Jun;19(2):99-100. No abstract available. PMID: 28651502

 

Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial.

Skrifvars MB, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group. J Trauma Acute Care Surg. 2017 Sep;83(3):449-456. doi: 10.1097/TA.0000000000001594. PMID: 28590358

 

Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research.

Gobat NH, Butler CC, Webb SAR, Nichol A; PREPARE-EARL Study Team. J Crit Care. 2017 Aug;40:271. doi: 10.1016/j.jcrc.2017.03.019. Epub 2017 Mar 27. No abstract available. PMID: 28438372

 

Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis.

Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, Bellomo R; EPO-TBI Investigators; and the ANZICS Clinical Trials Group. Ann Surg. 2018 Mar;267(3):585-589. doi: 10.1097/SLA.0000000000002142.

PMID: 28151802

 

Craniectomy for Traumatic Intracranial Hypertension.

Cooper DJ, Nichol A, Hodgson C. N Engl J Med. 2016 Dec 15;375(24):2402. No abstract available. PMID: 28032966

 

Venous thromboembolic events in critically ill traumatic brain injury patients.

Skrifvars MB, Bailey M, Presneill J, French C, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group. Intensive Care Med. 2017 Mar;43(3):419-428. doi: 10.1007/s00134-016-4655-2. Epub 2016 Dec 27. PMID: 28028552

 

Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study.

Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, Larsson A, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Am J Respir Crit Care Med. 2017 Jan 1;195(1):67-77. doi: 10.1164/rccm.201606-1306OC. PMID: 27753501

 

Who Says There Is No "I" in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care.

Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S; International Forum for Acute Care Trialists. Am J Respir Crit Care Med. 2016 Oct 1;194(7):911-912. No abstract available. PMID: 27689708

 

Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective.

Glassford NJ, Mårtensson J, Eastwood GM, Jones SL, Tanaka A, Wilkman E, Bailey M, Bellomo R; GLobal OBservational Evaluations in the ICU (GLOBE-ICU) investigators. J Crit Care. 2016 Oct;35:126-32. doi: 10.1016/j.jcrc.2016.05.017. Epub 2016 May 26. PMID: 27481747

 

Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis.

French CJ, Glassford NJ, Gantner D, Higgins AM, Cooper DJ, Nichol A, Skrifvars MB, Imberger G, Presneill J, Bailey M, Bellomo R. Ann Surg. 2017 Jan;265(1):54-62. doi: 10.1097/SLA.0000000000001746. Review. PMID: 27070933

 

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.

Cooper DJ, Nichol A, Presneill J. N Engl J Med. 2016 Apr 7;374(14):1384. doi: 10.1056/NEJMc1600339. No abstract available. PMID: 27050215

 

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum in: JAMA. 2016 Jul 19;316(3):350JAMA. 2016 Jul 19;316(3):350. PMID: 26903337

 

Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness.

Gobat NH, Gal M, Francis NA, Hood K, Watkins A, Turner J, Moore R, Webb SA, Butler CC, Nichol A. Trials. 2015 Dec 29;16:591. doi: 10.1186/s13063-015-1110-6. Review. PMID: 26715077

 

Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.

Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars M, Vallance S, Varma D, Wills J, Bellomo R; EPO-TBI Investigators; ANZICS Clinical Trials Group. Lancet. 2015 Dec 19;386(10012):2499-506. doi: 10.1016/S0140-6736(15)00386-4. Epub 2015 Oct 6. PMID:26452709

 

Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury.

Nichol A, Gantner D, Presneill J, Murray L, Trapani T, Bernard S, Cameron P, Capellier G, Forbes A, McArthur C, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Walker T, Webb S, Cooper DJ. Crit Care Resusc. 2015 Jun;17(2):92-100. PMID: 26017126

 

Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial.

Nichol A, French C, Little L, Presneill J, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Trials. 2015 Feb 8;16:39. doi: 10.1186/s13063-014-0528-6. PMID: 25884605

 

Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury.

Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators; ANZICS Clinical Trials Group. Trials. 2014 Dec 20;15:501. doi: 10.1186/1745-6215-15-501. PMID: 25528574

 

A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan.

Kaukonen KM, Bailey M, Ady B, Aubron C, French C, Gantner D, Irving D, Murray L, Nichol A, Pettilä V, McQuilten Z, Cooper DJ. Crit Care Resusc. 2014 Dec;16(4):255-61. PMID: 25437218

 

Erythropoietin for traumatic brain injury.

Nichol A, Little L, French C. JAMA. 2014 Nov 12;312(18):1928-9. doi: 10.1001/jama.2014.12738. No abstract available. PMID:25387193

 

Simvastatin in the acute respiratory distress syndrome.

McAuley DF, Laffey JG, O'Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C; HARP-2 Investigators; Irish Critical Care Trials Group.

N Engl J Med. 2014 Oct 30;371(18):1695-703. doi: 10.1056/NEJMoa1403285. Epub 2014 Sep 30. Erratum in: N Engl J Med. 2016 Nov 17;375(20):2010. PMID: 25268516

 

Open source clinical science for emerging infections.

Dunning JW, Merson L, Rohde GGU, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere KS, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien TT, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T; ISARIC Working Group 3, ISARIC Council, Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJM, Farrar J, Carson G, Baillie JK. Lancet Infect Dis. 2014 Jan;14(1):8-9. doi: 10.1016/S1473-3099(13)70327-X. No abstract available. PMID: 24355025

 

Australasian Resuscitation In Sepsis Evaluation trial statistical analysis plan.

Delaney A, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J, Webb S; ARISE Investigators. Emerg Med Australas. 2013 Oct;25(5):406-15. doi: 10.1111/1742-6723.12116. Epub 2013 Sep 9. PMID: 24099368

 

The Australasian Resuscitation in Sepsis Evaluation (ARISE) trial statistical analysis plan.

Delaney AP, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J, Webb S; ARISE investigators. Crit Care Resusc. 2013 Sep;15(3):162-71. Review. PMID: 23944201

 

A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis.

Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, Howe B, Jones D, Joyce C, Kostner K, McNeil J, Nichol A, Roberts MS, Syres G, Venkatesh B; ANZ-STATInS Investigators–ANZICS Clinical Trials Group. Am J Respir Crit Care Med. 2013 Apr 1;187(7):743-50. doi: 10.1164/rccm.201209-1718OC. PMID: 23348980

 

Age of red blood cells and transfusion in critically ill patients.

Aubron C, Nichol A, Cooper DJ, Bellomo R. Ann Intensive Care. 2013 Jan 15;3(1):2. doi: 10.1186/2110-5820-3-2. PMID: 23316800

 

Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one?

Hodgson C, Carteaux G, Tuxen DV, Davies AR, Pellegrino V, Capellier G, Cooper DJ, Nichol A. Injury. 2013 Dec;44(12):1700-9. doi: 10.1016/j.injury.2012.11.017. Epub 2012 Dec 21. Review. PMID:23261071

 

Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia.

Hodgson CL, Hayes K, Everard T, Nichol A, Davies AR, Bailey MJ, Tuxen DV, Cooper DJ, Pellegrino V. Crit Care. 2012 Oct 19;16(5):R202. doi: 10.1186/cc11811. PMID:23082772

 

The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke.

Young P, Beasley R, Bailey M, Bellomo R, Eastwood GM, Nichol A, Pilcher DV, Yunos NM, Egi M, Hart GK, Reade MC, Cooper DJ; Study of Oxygen in Critical Care (SOCC) Group. Crit Care Resusc. 2012 Mar;14(1):14-9. PMID:22404056

 

Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study.

Praeger AJ, Westbrook AJ, Nichol AD, Wijemunige R, Davies AR, Lyon SM, Wills JL, Bailey M, Rosenfeld JV, Cooper DJ. Crit Care Resusc. 2012 Mar;14(1):10-3. PMID: 22404055

 

Letter by Bellomo et al regarding article, "Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest".

Bellomo R, Bailey M, Nichol A. Circulation. 2012 Jan 24;125(3):e288; author reply e289. doi: 10.1161/CIRCULATIONAHA.111.053611. No abstract available. PMID: 2271854

 

A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients.

Aubron C, Syres G, Nichol A, Bailey M, Board J, Magrin G, Murray L, Presneill J, Sutton J, Vallance S, Morrison S, Bellomo R, Cooper DJ. Transfusion. 2012 Jun;52(6):1196-202. doi: 10.1111/j.1537-2995.2011.03437.x. Epub 2011 Nov 14. PMID:22082281

 

Dynamic lactate indices as predictors of outcome in critically ill patients.

Nichol A, Bailey M, Egi M, Pettila V, French C, Stachowski E, Reade MC, Cooper DJ, Bellomo R. Crit Care. 2011;15(5):R242. doi: 10.1186/cc10497. Epub 2011 Oct 20. PMID: 22014216

 

Permissive hypercapnia in acute respiratory distress syndrome - is now the time to get strict?

Nichol AD. Crit Care Resusc. 2011 Sep;13(3):142-3. No abstract available. PMID: 21879999

 

A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome.

Hodgson CL, Tuxen DV, Davies AR, Bailey MJ, Higgins AM, Holland AE, Keating JL, Pilcher DV, Westbrook AJ, Cooper DJ, Nichol AD. Crit Care. 2011;15(3):R133. doi: 10.1186/cc10249. Epub 2011 Jun 2. PMID: 21635753

 

Hypothermia in patients with brain injury: the way forward?

Nichol AD, Trapani T, Murray L, Vallance S, Cooper DJ. Lancet Neurol. 2011 May;10(5):405; author reply 406-7. doi: 10.1016/S1474-4422(11)70085-0. No abstract available. PMID: 21511193

 

Age of red blood cells and mortality in the critically ill.

Pettilä V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips LE, Street A, French C, Murray L, Orford N, Santamaria JD, Bellomo R, Cooper DJ; Blood Observational Study Investigators for ANZICS Clinical Trials Group. Crit Care. 2011;15(2):R116. doi: 10.1186/cc10142. Epub 2011 Apr 15. PMID: 21496231

 

Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury.

Moore EM, Nichol AD, Bernard SA, Bellomo R. Injury. 2011 Sep;42(9):843-54. doi: 10.1016/j.injury.2011.03.027. Epub 2011 Apr 9. Review. PMID:21481385

 

Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest.

Bellomo R, Bailey M, Eastwood GM, Nichol A, Pilcher D, Hart GK, Reade MC, Egi M, Cooper DJ; Study of Oxygen in Critical Care (SOCC) Group. Crit Care. 2011;15(2):R90. doi: 10.1186/cc10090. Epub 2011 Mar 8. PMID:21385416

 

Early outcome prediction after severe traumatic brain injury: can multimodal magnetic resonance imaging assist in clinical prognostication for individual patients?

Nichol AD, Toal F, Fedi M, Cooper DJ. Crit Care Resusc. 2011 Mar;13(1):5-8. No abstract available. PMID:21355822

 

Ionized calcium concentration and outcome in critical illness.

Egi M, Kim I, Nichol A, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M, Bellomo R. Crit Care Med. 2011 Feb;39(2):314-21. doi: 10.1097/CCM.0b013e3181ffe23e. PMID:21099425

 

The incidence of acute kidney injury in patients with traumatic brain injury.

Moore EM, Bellomo R, Nichol A, Harley N, Macisaac C, Cooper DJ. Ren Fail. 2010;32(9):1060-5. doi: 10.3109/0886022X.2010.510234. PMID:20863210

 

Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.

Nichol AD, O'Cronin DF, Naughton F, Hopkins N, Boylan J, McLoughlin P. Anesthesiology. 2010 Jul;113(1):116-25. doi: 10.1097/ALN.0b013e3181dfd2fe. PMID: 20526182

 

Challenging issues in randomised controlled trials.

Nichol AD, Bailey M, Cooper DJ; POLAR; EPO Investigators. Injury. 2010 Jul;41 Suppl 1:S20-3. doi: 10.1016/j.injury.2010.03.033. Epub 2010 Apr 22. PMID:20413119

 

Expensive care - a rationale for economic evaluations in intensive care.

Higgins AM, Pettila V, Bellomo R, Harris AH, Nichol AD, Morrison SS. Crit Care Resusc. 2010 Mar;12(1):62-6. Review. PMID:20196716

 

Venous thromboembolism prophylaxis in the critically ill: a point prevalence survey of current practice in Australian and New Zealand intensive care units.

Robertson MS, Nichol AD, Higgins AM, Bailey MJ, Presneill JJ, Cooper DJ, Webb SA, McArthur C, MacIsaac CM; VTE Point Prevalence Investigators for the Australian and New Zealand Intensive Care Research Centre; Australian and New Zealand Intensive Care Society Clinical Trials Group. Crit Care Resusc. 2010 Mar;12(1):9-15. PMID:20196708

 

Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study.

Nichol AD, Egi M, Pettila V, Bellomo R, French C, Hart G, Davies A, Stachowski E, Reade MC, Bailey M, Cooper DJ. Crit Care. 2010;14(1):R25. doi: 10.1186/cc8888. Epub 2010 Feb 24. PMID: 20181242

 

Hypercapnia and acidosis in sepsis: a double-edged sword?

Curley G, Contreras MM, Nichol AD, Higgins BD, Laffey JG. Anesthesiology. 2010 Feb;112(2):462-72. doi: 10.1097/ALN.0b013e3181ca361f. Review. PMID:20068449

 

Prospective observational study of postoperative complications after percutaneous dilatational or surgical tracheostomy in critically ill patients.

Barbetti JK, Nichol AD, Choate KR, Bailey MJ, Lee GA, Cooper DJ. Crit Care Resusc. 2009 Dec;11(4):244-9. PMID:20001871

 

Red blood cell transfusion and mortality.

Pettilä V, Nichol AD, Bellomo R, Cooper DJ. Crit Care Med. 2009 Nov;37(11):2996-7; author reply 2997. doi: 10.1097/CCM.0b013e3181b4a0a5. No abstract available. PMID: 19851147

 

Critical care services and 2009 H1N1 influenza in Australia and New Zealand.

ANZIC Influenza Investigators, Webb SA, Pettilä V, Seppelt I, Bellomo R, Bailey M, Cooper DJ, Cretikos M, Davies AR, Finfer S, Harrigan PW, Hart GK, Howe B, Iredell JR, McArthur C, Mitchell I, Morrison S, Nichol AD, Paterson DL, Peake S, Richards B, Stephens D, Turner A, Yung M. N Engl J Med. 2009 Nov 12;361(20):1925-34. doi: 10.1056/NEJMoa0908481. Epub 2009 Oct 8. PMID:19815860

 

Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis.

Nichol AD, O'Cronin DF, Howell K, Naughton F, O'Brien S, Boylan J, O'Connor C, O'Toole D, Laffey JG, McLoughlin P. Crit Care Med. 2009 Nov;37(11):2953-61. doi: 10.1097/CCM.0b013e3181b028ce. PMID: 19773647

 

Can we improve neurological outcomes in severe traumatic brain injury? Something old (early prophylactic hypothermia) and something new (erythropoietin).

Nichol AD, Cooper DJ; POLAR Study Investigators on behalf of the ANZICS-Clinical Trials Group; EPO Study Investigators on behalf of the ANZICS-Clinical Trials Group. Injury. 2009 May;40(5):471-8. doi: 10.1016/j.injury.2009.01.002. Epub 2009 Apr 15. Review. PMID: 19371869

 

Restrictive red blood cell transfusion strategies in critical care: does one size really fit all?

Nichol AD. Crit Care Resusc. 2008 Dec;10(4):323-7. Review. PMID: 19049485

 

Is it too early to recommend a restrictive transfusion strategy in critically ill patients with ischemic heart disease?

Nichol AD, Westbrook A, Bellomo R, Cooper DJ. Crit Care Med. 2008 Nov;36(11):3126-7; author reply 3127. doi: 10.1097/CCM.0b013e31818be422. No abstract available. PMID: 18941333

 

Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury.

O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P. Crit Care Med. 2008 Jul;36(7):2128-35. doi: 10.1097/CCM.0b013e31817d1b59. PMID: 18552698

 

High-frequency oscillation in acute respiratory distress syndrome: who rescues the rescuer?

Nichol A. Crit Care Med. 2007 Jun;35(6):1619-20. No abstract available. PMID: 17522538

 

Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.

Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. Circ Res. 2005 Jul 22;97(2):185-91. Epub 2005 Jun 16. PMID: 15961717