ICC-CTN Research Trials

PHARLAP

PHARLAP

The PHARLAP-RCT is a prospective, multi-centre, randomised controlled trial of the clinical efficacy of a ventilation strategy (called PHARLAP) compared to standard mechanical ventilation in acute respiratory distress syndrome (ARDS). This trial will be collaboration between Intensive Care Units of the Irish Critical Care- Clinical Trails Group (ICC- CTG) and the Australian and New Zealand Intensive Care Society- Clinical Trials Group (ANZICS-CTG).

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TRANSFUSE

TRANSFUSE

TRANSFUSE-RCT is a multi-centre, randomised, controlled trial, testing the effect of the freshest available red blood cell (RBC) unit compared to standard practice, on mortality in critically ill patients who require RBC transfusion.

The results have recently been presented at ESICM2017 in Vienna and published in the New England Journal of Medicine.

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REST

REST

The REST trial is pragmatic randomised controlled trial to determine whether Veno-Venous Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) in mechanically ventilated patients with hypoxaemic respiratory failure improves 90 day mortality.

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HARP II

HARP II

In this multicenter, double-blind clinical trial, patients with an onset of ARDS within the previous 48 hours were randomly assigned (in a 1:1 ratio) to receive enteral simvastatin at a dose of 80 mg or placebo once daily for a maximum of 28 days.

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POINT PREVALANCE

POINT PREVALANCE

This program acts as an observational study, without any intervention, and involves collecting data on topics of interest, in patients in multiple intensive care units, on a specific day or days. It provides no information on outcomes, but provides very important information on how common a problem is, and what is currently being done to manage that problem. This is an ongoing program consisting of multiple research collection days, each performing multiple, independent studies simultaneously, including a number of paediatric studies.

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PEPTIC

PEPTIC

PEPTIC is a multi-centre, cluster crossover, randomised trial comparing proton pump inhibitors (PPIs) with histamine-2 receptor blockers (H2RBs) for ulcer prophylaxis in mechanically ventilated ICU patients. The overall objective of this study is to establish the risk of in-hospital death using PPIs vs. H2RBs for routine ulcer prophylaxis in mechanically ventilated patients in the ICU.

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SPICE III

SPICE III

SPICE III is a prospective, un-blinded, randomised controlled trial of Early Goal-Directed Sedation (EGDS) compared with standard care. The study will recruit patients who are intubated and ventilated in a participating ICU, are expected to remain intubated the day after enrolment and need immediate and ongoing sedation

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ARISE

ARISE

The ARISE RCT was a multi-centre, randomised controlled trial of the effect of early goal-directed therapy, compared to standard care, on 90-day mortality in patients presenting to the Emergency Department with severe sepsis.

Patients were randomised in the ED to receive either EGDT for a total of 6 hours post-randomisation, or standard care. Patients assigned to receive EGDT were cared for by the dedicated ARISE study team. The patient received treatment as per the study protocol for 6 hours with central blood oxygen levels as the target end-point, and then received standard care. Patients assigned to receive standard care continued to be cared for by the hospital team in accordance with current best practice. Patients in both groups received any additional treatment needed, such as antibiotics or surgery.

The study was conducted in multiple sites with 1600 patients enrolled in the study over a 2.5 year period

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EPO-TBI

EPO-TBI

EPO-TBI was an international, double-blind, randomised controlled trial investigating erythropoietin (EPO) treatment in over 600 patients with traumatic brain injury. The group has concluded that erythropoietin does not improve functional outcome at six months as would be shown by a reduction in the number of patients with an Extended Glasgow Outcome Scale (GOS-E) measure of 4 or lower. While there are some indications that EPO treatment might reduce mortality in patients with traumatic brain injury, rigorous future investigations are required in this patient population before its routine use could be recommended.

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TAME

TAME

The TAME Cardiac Arrest Trial is a 1700 patient pragmatic, parallel group, randomised controlled trial evaluating the effect of mild hypercarbia in resuscitated patients post cardiac arrest. This ANZICS Clinical Trials Group investigation is presently recruiting centres and patients.

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