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Publications

  • 2023

  • 2022

    • Early Active Mobilization during Mechanical Ventilation in the ICU. TEAM Study Investigators and the ANZICS Clinical Trials Group, Hodgson CL, Bailey M, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe BJ, Gould DW, Harrold M, Higgins AM, Hurford S, Iwashyna TJ, Serpa Neto A, Nichol AD, Presneill JJ, Schaller SJ, Sivasuthan J, Tipping CJ, Webb S, Young PJ. N Engl J Med. 2022 Oct 26. doi: 10.1056/NEJMoa2209083. Online ahead of print. PMID: 36286256
    • Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Robba C, Badenes R, Battaglini D, Ball L, Sanfilippo F, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young PJ, Eastwood G, Chew MS, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Martin A, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Grejs AM, Ebner F, Pelosi P; TTM2 Trial collaborators. Crit Care. 2022 Oct 21;26(1):323. doi: 10.1186/s13054-022- 04186-8. PMID: 36271410; PMCID: PMC9585831.
    • Comparative effectiveness of neutralising monoclonal antibodies in high risk COVID-19 patients: a Bayesian network meta-analysis. McConnell D, Harte M, Walsh C, Murphy D, Nichol A, Barry M, Adams R. Sci Rep. 2022 Oct 20;12(1):17561. doi: 10.1038/s41598-022-22431-6. PMID: 36266486; PMCID: PMC9583057.
    • An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalized patients. Gonçalves BP, Hall M, Jassat W, Balan V, Murthy S, Kartsonaki C, Semple MG, Rojek A, Baruch J, Reyes LF, Dasgupta A, Dunning J, Citarella BW, Pritchard M, Martín-Quiros A, Sili U, Baillie JK, Aryal D, Arabi Y, Rashan A, Angheben A, Caoili J, Carrier FM, Harrison EM, Gómez-Junyent J, Figueiredo-Mello C, Douglas JJ, Mat Nor MB, Chow YP, Wong XC, Bertagnolio S, Thwin SS, Streinu-Cercel A, Salazar L, Rishu A, Rangappa R, Ong DSY, Hashmi M, Carson G, Diaz J, Fowler R, Kraemer MUG, Wils EJ, Horby P, Merson L, Olliaro PL; ISARIC Clinical Characterisation Group. Elife. 2022 Oct 5;11:e80556. doi: 10.7554/eLife.80556. PMID: 36197074; PMCID: PMC9534549.
    • Respiratory Support in the Time of COVID-19. Nichol AD, O'Kane C, McAuley DF. JAMA. 2022 Sep 27;328(12):1203-1205. doi: 10.1001/jama.2022.15229. PMID: 36166049.
    • Galectin-3 Inhibition in COVID-19. Reddy K, Nichol A, McAuley DF. Am J Respir Crit Care Med. 2022 Sep 26. doi: 10.1164/rccm.202209-1758ED. Epub ahead of print. PMID: 36154818.
    • Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Reyes LF, Murthy S, Garcia- Gallo E, Merson L, Ibáñez-Prada ED, Rello J, Fuentes YV, Martin-Loeches I, Bozza F, Duque S, Taccone FS, Fowler RA, Kartsonaki C, Gonçalves BP, Citarella BW, Aryal D, Burhan E, Cummings MJ, Delmas C, Diaz R, Figueiredo-Mello C, Hashmi M, Panda PK, Jiménez MP, Rincon DFB, Thomson D, Nichol A, Marshall JC, Olliaro PL; ISARIC Characterization Group. Crit Care. 2022 Sep 13;26(1):276. doi: 10.1186/s13054- 022-04155-1. PMID: 36100904; PMCID: PMC9469080.
    • A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal- Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Zampieri FG, da Costa BR, Vaara ST, Lamontagne F, Rochwerg B, Nichol AD, McGuinness S, McAuley DF, Ostermann M, Wald R, Bagshaw SM; STARRT-AKI Investigators. Crit Care. 2022 Aug 25;26(1):255. doi: 10.1186/s13054-022-04120-y. PMID: 36008827; PMCID: PMC9404618.
    • Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups-practical guidance to support better practice. Dawson S, Banister K, Biggs K, Cotton S, Devane D, Gardner H, Gillies K, Gopalakrishnan G, Isaacs T, Khunti K, Nichol A, Parker A, Russell AM, Shepherd V, Shiely F, Shorter G, Starling B, Williams H, Willis A, Witham MD, Treweek S. Trials.
      2022 Aug 17;23(1):672. doi: 10.1186/s13063-022-06553-w. Erratum in: Trials.
      2022 Sep 7;23(1):760. PMID: 35978338; PMCID: PMC9383663.
    • Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set. Conway Morris A, Kohler K, De Corte T, Ercole A, De Grooth HJ, Elbers PWG, Povoa P, Morais R, Koulenti D, Jog S, Nielsen N, Jubb A, Cecconi M, De Waele J; ESICM UNITE COVID investigators. Crit Care. 2022 Aug 3;26(1):236. doi: 10.1186/s13054-022-04108-8. Erratum in: Crit Care. 2022 Aug 17;26(1):249. PMID: 35922860; PMCID: PMC9347163.
    • ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. ISARIC Clinical Characterization Group, Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. Sci Data. 2022 Jul 30;9(1):454. doi: 10.1038/s41597-022- 01534-9. PMID: 35908040; PMCID: PMC9339000.
    • Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of- hospital cardiac arrest (TTM2) trial. Robba C, Badenes R, Battaglini D, Ball L, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young PJ, Eastwood G, Chew MS, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Annborn M, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Pelosi P; TTM2 Trial Collaborators. Intensive Care Med. 2022 Aug;48(8):1024- 1038. doi: 10.1007/s00134-022-06756-4. Epub 2022 Jul 2. PMID: 35780195; PMCID: PMC9304050.
    • Prophylaxis in healthcare workers during a pandemic: a model for a multi- centre international randomised controlled trial using Bayesian analyses. Bruce P, Ainscough K, Hatter L, Braithwaite I, Berry LR, Fitzgerald M, Hills T, Brickell K, Cosgrave D, Semprini A, Morpeth S, Berry S, Doran P, Young P, Beasley R, Nichol A. Trials. 2022 Jun 27;23(1):534. doi: 10.1186/s13063-022-06402-w. Erratum in: Trials. 2022 Jul 5;23(1):546. PMID: 35761370; PMCID: PMC9235209.
    • People in intensive care with COVID-19: demographic and clinical features during the first, second, and third pandemic waves in Australia. Begum H, Neto AS, Alliegro P, Broadley T, Trapani T, Campbell LT, Cheng AC, Cheung W, Cooper DJ, Erickson SJ, French CJ, Litton E, McAllister R, Nichol A, Palermo A,
      Plummer MP, Rotherham H, Ramanan M, Reddi B, Reynolds C, Webb SA, Udy AA, Burrell A. Med J Aust. 2022 Jun 9. doi: 10.5694/mja2.51590. Epub ahead of print. PMID: 35686307.
    • Biomarkers of brain injury after cardiac arrest; a statistical analysis plan from the TTM2 trial biobank investigators. Moseby-Knappe M, Levin H, Blennow K, Ullén S, Zetterberg H, Lilja G, Dankiewicz J, Jakobsen JC, Lagebrant A, Friberg H, Nichol A, Ainschough K, Eastwood GM, Wise MP, Thomas M, Keeble T, Cariou A, Leithner C, Rylander C, Düring J, Bělohlávek J, Grejs A, Borgquist O, Undén J, Simon M, Rolny V, Piehler A, Cronberg T, Nielsen N. Resusc Plus. 2022 Jun 2;10:100258. doi: 10.1016/j.resplu.2022.100258. PMID: 35677835; PMCID: PMC9168690.
    • Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis. Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NKJ, Angriman F, Goligher EC. Am J Respir Crit Care Med. 2022 Jun 1;205(11):1300-1310. doi: 10.1164/rccm.202108- 1972OC. PMID: 35180042.
    • Development of the Consumer Involvement & Engagement Toolkit: a digital resource to build capacity for undertaking patient-centred clinical trials in Australia. Symons T, Bowden J, McKenzie A, Fallon-Ferguson JM, Weekes LY, Ansell J, Murphy R, Jesudason S, Saxena M, Nichol A, Straiton N. Public Health Res Pract. 2022 Jun 1:32122209. doi: 10.17061/phrp32122209. Online ahead of print. PMID: 35661863
    • Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study. Greco M, De Corte T, Ercole A, Antonelli M, Azoulay E, Citerio G, Morris AC, De Pascale G, Duska F, Elbers P, Einav S, Forni L, Galarza L, Girbes ARJ, Grasselli G, Gusarov V, Jubb A, Kesecioglu J, Lavinio A, Delgado MCM, Mellinghoff J, Myatra SN, Ostermann M, Pellegrini M, Povoa P, Schaller SJ, Teboul JL, Wong A, De Waele JJ, Cecconi M; ESICM UNITE- COVID investigators. Intensive Care Med. 2022 May 21:1-16. doi: 10.1007/s00134-022-06705-1. Online ahead of print. PMID: 35596752 Correction to: Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study. Intensive Care Med. 2022 Aug;48(8):1130-1131. doi: 10.1007/s00134-022-06801-2. Early short course of neuromuscular blocking agents in patients with COVID- 19 ARDS: a propensity score analysis. Li Bassi G, Gibbons K, Suen JY, Dalton HJ, White N, Corley A, Shrapnel S, Hinton S, Forsyth S, Laffey JG, Fan E, Fanning JP, Panigada M, Bartlett R, Brodie D, Burrell A, Chiumello D, Elhazmi A, Esperatti M, Grasselli G, Hodgson C, Ichiba S, Luna C, Marwali E, Merson L, Murthy S, Nichol A, Ogino M, Pelosi P, Torres A, Ng PY, Fraser JF; COVID-19 Critical Care Consortium. Crit Care. 2022 May 17;26(1):141. doi: 10.1186/s13054-022-03983-5. PMID: 35581612
    • Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. Wainstein M, MacDonald S, Fryer D, Young K, Balan V, Begum H, Burrell A, Citarella BW, Cobb JP, Kelly S, Kennon K, Lee J, Merson L, Murthy S, Nichol A, Semple MG, Strudwick S, Webb SA, Rossignol P, Claure-Del Granado R, Shrapnel S; ISARIC Clinical Characterisation Group. PLoS Med. 2022 Apr 20;19(4):e1003969. doi: 10.1371/journal.pmed.1003969. Epub ahead of print. PMID: 35442972.
    • Effects of brain tissue oxygen (PbtO2) guided management on patient outcomes following severe traumatic brain injury: A systematic review and meta-analysis. Hays LMC, Udy A, Adamides AA, Anstey JR, Bailey M, Bellapart J, Byrne K, Cheng A, Jamie Cooper D, Drummond KJ, Haenggi M, Jakob SM, Higgins AM, Lewis PM, Hunn MK, McNamara R, Menon DK, Murray L, Reddi B, Trapani T, Vallance S, Young PJ, Diaz-Arrastia R, Shutter L, Murray PT, Curley GF, Nichol A. J Clin Neurosci. 2022 Mar 29;99:349-358. doi: 10.1016/j.jocn.2022.03.017. Epub ahead of print. PMID: 35364437.
    • Economic evaluations for intensive care unit randomised clinical trials in Australia and New Zealand: Practical recommendations for researchers. Taylor CB, Thompson KJ, Hodgson C PhD, Liew C MPH, Litton E MBChB, FCICM, PhD, McGain F FANZCA, FCICM, PhD, Nichol A PhD, Rauniyar R MPH, Ridley E PhD, Higgins A PhD. Aust Crit Care. 2022 Mar 24:S1036-7314(22)00028-5. doi: 10.1016/j.aucc.2022.02.002. Epub ahead of print. PMID: 35341668.
    • Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study. Sato K, White N, Fanning JP, Obonyo N, Yamashita MH, Appadurai V, Ciullo A, May M, Worku ET, Helms L, Ohshimo S, Juzar DA, Suen JY, Bassi GL, Fraser JF, Arora RC; COVID-19 Critical Care Consortium Investigators. BMC Cardiovasc Disord. 2022 Mar 23;22(1):123. doi: 10.1186/s12872-022-02565-1. PMID:
      35321649; PMCID: PMC8942148.
    • Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. REMAP- CAP Writing Committee for the REMAP-CAP Investigators, Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910. PMID: 35315874.
    • Whole genome sequencing reveals host factors underlying critical Covid-19. Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC Investigators; 23andMe; Covid-19 Human Genetics Initiative, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Nature. 2022 Mar 7. doi: 10.1038/s41586-022-04576-6. Epub ahead of print. PMID: 35255492.
    • Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. Robba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L, Brunetti I, Pedro David WG, Young P, Eastwood G, Chew MS, Jakobsen J, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Lilja G, Hammond NE, Saxena M, Martin A, Solar M, Taccone FS, Friberg HA, Pelosi P. BMJ Open. 2022 Mar 3;12(3):e058001. doi: 10.1136/bmjopen-2021-058001. PMID: 35241476; PMCID: PMC8896064.
    • Association of PEEP and Lung Recruitment Selection Strategies with
      Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-Analysis. Dianti J, Tisminetzky M, Ferreyro BL, Englesakis M, Del Sorbo L, Sud S, Talmor D, Ball L, Meade M, Hodgson C, Beitler JR, Sahetya S, Nichol A, Fan E, Rochwerg B, Brochard L, Slutsky AS, Ferguson ND, Serpa Neto A, Adhikari NK, Angriman F, Goligher EC. Am J Respir Crit Care Med. 2022 Feb 18. doi: 10.1164/rccm.202108-1972OC. Epub ahead of print. PMID: 35180042.
    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study. Reyes LF, Murthy S, Garcia-Gallo E, Irvine M, Merson L, Martin-Loeches I, Rello J, Taccone FS, Fowler RA, Docherty AB, Kartsonaki C, Aragao I, Barrett PW, Beane A, Burrell A, Cheng MP, Christian MD, Cidade JP, Citarella BW, Donnelly CA, Fernandes SM, French C, Haniffa R, Harrison EM, Ho AYW, Joseph M, Khan I, Kho ME, Kildal AB, Kutsogiannis D, Lamontagne F, Lee TC, Bassi GL, Lopez Revilla JW, Marquis C, Millar J, Neto R, Nichol A, Parke R, Pereira R, Poli S, Povoa P, Ramanathan K, Rewa O, Riera J, Shrapnel S, Silva MJ, Udy A, Uyeki T, Webb SA, Wils EJ, Rojek A, Olliaro PL; ISARIC Clinical Characterisation Group. ERJ Open Res. 2022 Feb 14;8(1):00552- 2021. doi: 10.1183/23120541.00552-2021. PMID: 35169585; PMCID: PMC8669808.
    • Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P; LUNG SAFE Investigators and the ESICM Trials Group. Lancet Respir Med. 2022 Apr;10(4):367-377. doi: 10.1016/S2213-2600(21)00461-6. Epub 2022 Jan 10. PMID: 35026177; PMCID: PMC8976729.

  • 2021

    • Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Pisani L, Algera AG, Neto AS, Azevedo L, Pham T, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Bellani G, Laffey JG, Schultz MJ; ERICC study investigators; LUNG SAFE study investigators; PRoVENT study investigators; PRoVENT-iMiC study investigators. Lancet Glob Health. 2021 Dec 13:S2214-109X(21)00485-X. doi: 10.1016/S2214-109X(21)00485-X. Epub ahead of print. PMID: 34914899.
    • Common, low-frequency, rare, and ultra-rare coding variants contribute to
      COVID-19 severity. Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R; WES/WGS Working Group Within the HGI; GenOMICC Consortium; GEN-COVID Multicenter Study, Mari F, Renieri A, Furini S. Hum Genet. 2021 Dec 10:1–27. doi: 10.1007/s00439-021-02397-7. Epub ahead of print. PMID: 34889978; PMCID: PMC8661833.
    • Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. ISARIC Clinical Characterisation Group, Hall MD, Baruch J, Carson G, Citarella BW, Dagens A, Dankwa EA, Donnelly CA, Dunning J, Escher M, Kartsonaki C, Merson L, Pritchard M, Wei J, Horby PW, Rojek A, Olliaro PL. Elife. 2021 Nov 23;10:e70970. doi: 10.7554/eLife.70970. PMID: 34812731; PMCID: PMC8791638.
    • Association between convalescent plasma treatment and mortality in COVID- 19: a collaborative systematic review and meta-analysis of randomized clinical trials. Axfors C, Janiaud P, Schmitt AM, …, Nichol AD, Nielsen H, Novak RM, O'Sullivan MVN, Olalla J, Osibogun A, Osikomaiya B, Oyonarte S, Pardo-Oviedo JM, Patel MC, Paterson DL, Peña-Perez CA, Perez-Calatayud AA, Pérez-Alba E, Perkina A, Perry N, Pouladzadeh M, Poyato I, Price DJ, Quero AKH, Rahman MM, Rahman MS, Ramesh M, Ramírez-Santana C, Rasmussen M, Rees MA, Rego E, Roberts JA, Roberts DJ, Rodríguez Y, Rodríguez-Baño J, Rogers BA, Rojas M, Romero A, Rowan KM, Saccona F, Safdarian M, Santos MCM, Sasadeusz J, Scozzari G, Shankar-Hari M, Sharma G, Snelling T, Soto A, Tagayuna PY, Tang A, Tatem G, Teofili L, Tong SYC, Turgeon AF, Veloso JD, Venkatesh B, Ventura-Enriquez Y, Webb SA, Wiese L, Wikén C, Wood EM, Yusubalieva GM, Zacharowski K, Zarychanski R, Khanna N, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. BMC Infect Dis. 2021 Nov 20;21(1):1170. doi: 10.1186/s12879-021-06829-7. PMID: 34800996; PMCID: PMC8605464.
    • Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study. Li Bassi G, Suen JY, White N, Dalton HJ, Fanning J, Corley A, Shrapnel S, Hinton S, Forsyth S, Parsons R, Laffey JG, Fan E, Bartlett R, Brodie D, Burrell A, Chiumello D, Elhazmi A, Grasselli G, Hodgson C, Ichiba S, Luna C, Marwali E, Merson L, Murthy S, Nichol A, Panigada M, Pelosi P, Torres A, Ng PY, Ogino M, Fraser JF. Crit Care Explor. 2021 Nov 5;3(11):e0567. doi: 10.1097/CCE.0000000000000567. PMID: 34765979; PMCID: PMC8575423.
    • The value of open-source clinical science in pandemic response: lessons from
      ISARIC. ISARIC Clinical Characterisation Group. Lancet Infect Dis. 2021 Dec;21(12):1623-1624. doi: 10.1016/S1473-3099(21)00565-X. Epub 2021 Oct 4.
      Erratum in: Lancet Infect Dis. 2021 Dec;21(12):e363. PMID: 34619109; PMCID: PMC8489876.
    • Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. Writing Committee for the REMAP-CAP Investigators, Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Bégin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chassé M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. JAMA. 2021 Nov 2;326(17):1690- 1702. doi: 10.1001/jama.2021.18178. PMID: 34606578
    • Normalising comparative effectiveness trials as clinical practice. Briffa T, Symons T, Zeps N, Straiton N, Tarnow-Mordi WO, Simes J, Harris IA, Cruz M, Webb SA, Litton E, Nichol A, Williams CM. Trials. 2021 Sep 15;22(1):620. doi: 10.1186/s13063-021-05566-1. PMID: 34526083; PMCID: PMC8442385.
    • Urinary biomarkers predict progression and adverse outcomes of acute kidney injury in critical illness. Duff S, Irwin R, Cote JM, Redahan L, McMahon BA, Marsh B, Nichol A, Holden S, Doran P, Murray PT. Nephrol Dial Transplant. 2021 Sep 7:gfab263. doi: 10.1093/ndt/gfab263. Epub ahead of print. PMID: 34491355.
    • Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Ehrmann S, Li J, Ibarra-Estrada M, Perez Y, Pavlov I, McNicholas B, Roca O, Mirza S, Vines D, Garcia-Salcido R, Aguirre-Avalos G, Trump MW, Nay MA, Dellamonica J, Nseir S, Mogri I, Cosgrave D, Jayaraman D, Masclans JR, Laffey JG, Tavernier E; Awake Prone Positioning Meta-Trial Group. Lancet Respir Med. 2021 Aug 20:S2213- 2600(21)00356-8. doi: 10.1016/S2213-2600(21)00356-8. Epub ahead of print. PMID: 34425070; PMCID: PMC8378833.
    • A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). Deane AM, Jiang A, Tascone B, Clancy A, Finnis ME, Collie JT, Greaves R, Byrne KM, Fujii T, Douglas JS, Nichol A, Udy AA, Young M, Russo G, Fetterplace K, Maiden MJ, Plummer MP, Yanase F, Bellomo R, Ali Abdelhamid Y. Clin Nutr. 2021 Jul 24;40(8):5047-5052. doi: 10.1016/j.clnu.2021.07.024. Epub ahead of print. PMID: 34388414.
    • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong
      MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2103417. Epub ahead of print. PMID: 34351722.
    • Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2105911. Epub ahead of print. PMID: 34351721.
    • Inflammation, immunity and allergy. Stewart, D., Nichol, A. Anaesthesia and Intensive Care Medicine. 2021 Aug;22(8):488-493. DOI: 10.1016/j.mpaic.2021.06.004
    • Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Arabi YM, Gordon AC, Derde LPG, Nichol AD, Murthy S, Beidh FA, Annane D, Swaidan LA, Beane A, Beasley R, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Buzgau A, Cheng A, De Jong M, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Fowler R, Girard TD, Goligher EC, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Huang DT, King AJ, Lamontagne F, Lawler PR, Lewis R, Linstrum K, Litton E, Lorenzi E, Malakouti S, McAuley DF, McGlothlin A, Mcguinness S, McVerry BJ, Montgomery SK, Morpeth SC, Mouncey PR, Orr K, Parke R, Parker JC, Patanwala AE, Rowan KM, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tong SYC, Turgeon AF, Turner AM, Van de Veerdonk FL, Zarychanski R, Green C, Berry S, Marshall JC, McArthur C, Angus DC, Webb SA; REMAP-CAP Investigators. Intensive Care Med. 2021 Jul 12:1–20. doi: 10.1007/s00134-021-06448-5. Epub ahead of print. PMID: 34251506; PMCID: PMC8274471.
    • COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. ISARIC Clinical Characterisation Group. Infection. 2021 Jun 25:1–17. doi: 10.1007/s15010-021-01599-5. Epub ahead of print. PMID: 34170486; PMCID: PMC8231091.
    • Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S, Rylander C, Wise MP, Oddo M, Cariou A, Bělohlávek J, Hovdenes J, Saxena M, Kirkegaard H, Young PJ, Pelosi P, Storm C, Taccone FS, Joannidis M, Callaway C, Eastwood GM, Morgan MPG, Nordberg P, Erlinge D, Nichol AD, Chew MS, Hollenberg J, Thomas M, Bewley J, Sweet K, Grejs AM, Christensen S, Haenggi M, Levis A, Lundin A, Düring J, Schmidbauer S, Keeble TR, Karamasis GV, Schrag C, Faessler E, Smid O, Otáhal M, Maggiorini M, Wendel Garcia PD, Jaubert P, Cole JM, Solar M, Borgquist O, Leithner C, Abed-Maillard S, Navarra L, Annborn M, Undén J, Brunetti I, Awad A, McGuigan P, Bjørkholt Olsen R, Cassina T, Vignon P, Langeland H, Lange T, Friberg H, Nielsen N; TTM2 Trial Investigators. N Engl J Med. 2021 Jun 17;384(24):2283-2294. doi: 10.1056/NEJMoa2100591. PMID: 34133859.
    • An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Li Bassi G, Suen JY, Dalton HJ, White N, Shrapnel S, Fanning JP, Liquet B, Hinton S, Vuorinen A, Booth G, Millar JE, Forsyth S, Panigada M, Laffey J, Brodie D, Fan E, Torres A, Chiumello D, Corley A, Elhazmi A, Hodgson C, Ichiba S, Luna C, Murthy S, Nichol A, Ng PY, Ogino M, Pesenti A, Trieu HT, Fraser JF; COVID- 19 Critical Care Consortium. Crit Care. 2021 Jun 9;25(1):199. doi: 10.1186/s13054- 021-03518-4. PMID: 34108029; PMCID: PMC8188162.
    • Preparing accessible and understandable clinical research participant information leaflets and consent forms: a set of guidelines from an expert consensus conference. Coleman E, O'Sullivan L, Crowley R, Hanbidge M, Driver S, Kroll T, Kelly A, Nichol A, McCarthy O, Sukumar P, Doran P. Res Involv Engagem. 2021 May 18;7(1):31. doi: 10.1186/s40900-021-00265-2. PMID: 34006326; PMCID: PMC8130271.
    • Integration of Equipoise into Eligibility Criteria in the STARRT-AKI Trial. Wald R, Bagshaw SM; STARRT-AKI Investigators. Am J Respir Crit Care Med. 2021 May 3. doi: 10.1164/rccm.202009-3425LE. Epub ahead of print. PMID: 33939598.
    • Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis. Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, Saffery R, Nichol A, Colditz G, Short KR, Burgner DP; International BMI-COVID consortium; *International BMI-COVID consortium. Diabetes Care. 2021 Apr 15:dc202676. doi: 10.2337/dc20-2676. Epub ahead of print. PMID: 33858854.
    • Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shehzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. Nat Commun. 2021 Apr 15;12(1):2349. doi: 10.1038/s41467-021-22446-z. PMID:
      33859192. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta- analysis of randomized trials. Nat Commun. 2021 May 14;12(1):3001. doi: 10.1038/s41467-021-23559-1. Erratum for: Nat Commun. 2021 Apr 15;12(1):2349. PMID: 33990619; PMCID: PMC8121133.
    • Death in hospital following ICU discharge: insights from the LUNG SAFE study. Madotto F, McNicholas B, Rezoagli E, Pham T, Laffey JG, Bellani G; LUNG SAFE Investigators; ESICM Trials Group. Crit Care. 2021 Apr 13;25(1):144. doi: 10.1186/s13054-021-03465-0. PMID: 33849625; PMCID: PMC8043098.
    • Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. Shehabi Y, Serpa Neto A, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Kadiman SB, McArthur CJ, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; SPICE III Study Investigators. Intensive Care Med. 2021 Mar 8:1–12. doi: 10.1007/s00134-021-06356-8. Epub ahead of print. PMID: 33686482; PMCID:
      PMC7939103.
    • Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettilä V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG. N Engl J Med. 2021 Feb 25. doi: 10.1056/NEJMoa2100433. Online ahead of print. PMID: 33631065
    • A Post Hoc Analysis of Osmotherapy Use in the Erythropoietin in Traumatic Brain Injury Study-Associations With Acute Kidney Injury and Mortality. Skrifvars MB, Bailey M, Moore E, Mårtensson J, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi YM, McArthur C, Cooper DJ, Bendel S, Bellomo R; Erythropoietin in Traumatic Brain Injury (EPO-TBI) Investigators and the Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004853. Online ahead of print. PMID: 33566466
    • Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study. Fujii T, Udy AA, Nichol A, Bellomo R, Deane AM, El-Khawas K, Thummaporn N, Serpa Neto A, Bergin H, Short- Burchell R, Chen CM, Cheng KH, Cheng KC, Chia C, Chiang FF, Chou NK, Fazio T, Fu PK, Ge V, Hayashi Y, Holmes J, Hu TY, Huang SF, Iguchi N, Jones SL, Karumai T, Katayama S, Ku SC, Lai CL, Lee BJ, Liaw WJ, Ong CTW, Paxton L, Peppin C, Roodenburg O, Saito S, Santamaria JD, Shehabi Y, Tanaka A, Tiruvoipati R, Tsai HE, Wang AY, Wang CY, Yeh YC, Yu CJ, Yuan KC; SODA-BIC investigators. Crit Care. 2021 Feb 2;25(1):45. doi: 10.1186/s13054-020-03431-2. PMID: 33531020

  • 2020

    1. Acute kidney injury and the critically ill. Flood L, Nichol A. Anaesthesia and Intensive Care Medicine. 2021 Jan;22(2):121-127. DOI: 10.1016/j.mpaic.2020.12.004

    2. Care bundles for improving outcomes in patients with COVID-19 or related conditions in intensive care - a rapid scoping review. Smith V, Devane D, Nichol A, Roche D. Cochrane Database Syst Rev. 2020 Dec 21;12:CD013819. doi: 10.1002/14651858.CD013819. PMID: 33348427

    3. Outcomes for patients with COVID-19 admitted to Australian intensive care units during the first four months of the pandemic. Burrell AJ, Pellegrini B, Salimi F, Begum H, Broadley T, Campbell LT, Cheng AC, Cheung W, Cooper DJ, Earnest A, Erickson SJ, French CJ, Kaldor JM, Litton E, Murthy S, McAllister RE, Nichol AD, Palermo A, Plummer MP, Ramanan M, Reddi BA, Reynolds C, Trapani T, Webb SA, Udy AA. Med J Aust. 2021 Jan;214(1):23-30. doi: 10.5694/mja2.50883. Epub 2020 Dec 15. PMID: 33325070

    4. Genetic mechanisms of critical illness in Covid-19. Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira A, Renieri A; GenOMICC Investigators; ISARICC Investigators; COVID-19 Human Genetics Initiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVID Investigators, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Nature. 2020 Dec 11. doi: 10.1038/s41586- 020-03065-y. Online ahead of print. PMID: 33307546

    5. Clinician-researcher's perspectives on clinical research during the COVID19 pandemic. Silverberg SL, Puchalski Ritchie LM, Gobat N, Nichol A, Murthy S. PLoS One. 2020 Dec 9;15(12):e0243525. doi: 10.1371/journal.pone.0243525. eCollection 2020. PMID: 33296427

    6. Facing the Ethical Challenges: Consumer Involvement in COVID-19 Pandemic Research. Straiton N, McKenzie A, Bowden J, Nichol A, Murphy R, Snelling T, Zalcberg J, Clements J, Stubbs J, Economides A, Kent D, Ansell J, Symons T. J Bioeth Inq. 2020 Nov 9:1–6. doi: 10.1007/s11673-020-10060-5. Epub ahead of print. PMID: 33169265; PMCID: PMC7651817.

    7. Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan. Jakobsen JC, Dankiewicz J, Lange T, Cronberg T, Lilja G, Levin H, Bělohlávek J, Callaway C, Cariou A, Erlinge D, Hovdenes J, Joannidis M, Nordberg P, Oddo M, Pelosi P, Kirkegaard H, Eastwood G, Rylander C,

    8. Saxena M, Storm C, Taccone FS, Wise MP, Morgan MPG, Young P, Nichol A, Friberg H, Ullén S, Nielsen N. Trials. 2020 Oct 7;21(1):831. doi: 10.1186/s13063-020- 04654-y. PMID: 33028425

    9. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. Writing Committee for the REMAP-CAP Investigators, Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, Fitzgerald M, Goossens H, Green C, Haniffa R, Higgins AM, Horvat C, Hullegie SJ, Kruger P, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, Marshall J, McAuley D, McGlothin A, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Rowan K, Sanil A, Santos M, Saunders C, Seymour C, Turner A, van de Veerdonk F, Venkatesh B, Zarychanski R, Berry S, Lewis RJ, McArthur C, Webb SA, Gordon AC. JAMA. 2020 Oct 6;324(13):1317-1329. doi: 10.1001/jama.2020.17022. PMID: 32876697

    10. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. STARRT-AKI Investigators; Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the United Kingdom Critical Care Research Group, the Canadian Nephrology Trials Network, and the Irish Critical Care Trials Group, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Landoni G, Liu KD, McAuley DF, McGuinness SP, Neyra JA, Nichol AD, Ostermann M, Palevsky PM, Pettilä V, Quenot JP, Qiu H, Rochwerg B, Schneider AG, Smith OM, Thomé F, Thorpe KE, Vaara S, Weir M, Wang AY, Young P, Zarbock A. N Engl J Med. 2020 Jul 16;383(3):240-251. doi: 10.1056/NEJMoa2000741. PMID: 32668114

    11. Emerging pharmacological therapies for ARDS: COVID-19 and beyond. Horie S, McNicholas B, Rezoagli E, Pham T, Curley G, McAuley D, O'Kane C, Nichol A, Dos Santos C, Rocco PRM, Bellani G, Laffey JG. Intensive Care Med. 2020 Jul 11:1-19. doi: 10.1007/s00134-020-06141-z. Online ahead of print. PMID: 32654006

    12. Global outbreak research: harmony not hegemony. ISARIC clinical characterisation group. Lancet Infect Dis. 2020 Jul;20(7):770-772. doi: 10.1016/S1473-3099(20)30440-0. Epub 2020 Jun 2. PMID: 32502433

    13. Optimal ventilator settings after return of spontaneous circulation. Eastwood GM, Nichol A. Curr Opin Crit Care. 2020 Jun;26(3):251-258. doi: 10.1097/MCC.0000000000000720. PMID: 32348093

    14. Opportunities and challenges of clustering, crossing over, and using registry data in the PEPTIC trial. Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bellomo R, van Haren F, Litton E, Webb SA. Crit Care Resusc. 2020 Jun;22(2):105-109. PMID: 32389102

    15. In-Depth Extracorporeal Cardiopulmonary Resuscitation in Adult Out-of- Hospital Cardiac Arrest. Dennis M, Lal S, Forrest P, Nichol A, Lamhaut L, Totaro RJ, Burns B, Sandroni C. J Am Heart Assoc. 2020 May 18;9(10):e016521. doi: 10.1161/JAHA.120.016521. Epub 2020 May 6. PMID: 32375010

    16. ANZICS guiding principles for complex decision making during the COVID-19 pandemic. Warrillow S, Austin D, Cheung W, Close E, Holley A, Horgan B, Jansen M, Joynt G, Lister P, Moodie S, Nichol A, Nicholls M, Peake S, Skowronski G, Streat S, White B, Willmott L. Crit Care Resusc. 2020 Apr 15. Online ahead of print. PMID: 32294810

    17. The Randomized Embedded Multifactorial Adaptive Platform for Community- acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. Ann Am Thorac Soc. 2020 Apr 8. doi: 10.1513/AnnalsATS.202003- 192SD. Online ahead of print. PMID: 32267771

    18. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Crit Care. 2020 Mar 31;24(1):125. doi: 10.1186/s13054-020-2826-6. PMID: 32234077

    19. Characteristics and Outcomes of Critically Ill Trauma Patients in Australia and New Zealand (2005-2017). Wilson AJ, Magee F, Bailey M, Pilcher DV, French C, Nichol A, Udy A, Hodgson CL, Cooper DJ, Reade MC, Young P, Bellomo R. Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004284. [Epub ahead of print] PMID: 32108705

    20. The implications of the PEPTIC trial for clinical practice. Young PJ, Bagshaw SM, Bellomo R, Nichol AD, Wright SE. Crit Care Resusc. 2020 Mar;22(1):4-5. PMID: 32102637

    21. Gender differences in mortality and quality of life after septic shock: A post- hoc analysis of the ARISE study. Nora Luethi, Michael Bailey, AlisaHiggins, Belinda Howe, Sandra Peake, Anthony Delaney, Rinaldo Bellomo, ARISE investigators. J Crit Care. 2020;55:177-183. doi:10.1016/j.jcrc.2019.11.002 PMID: 31739087

    22. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine- 2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM. JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22190. [Epub ahead of print]PMID: 31950977

    23. Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis. McQuilten ZK, French CJ, Nichol A, Higgins A, Cooper DJ. Transfus Med Rev. 2018 Apr;32(2):77-88. doi: 10.1016/j.tmrv.2018.02.002. Epub 2018 Feb 17. Review. PMID: 29526337. Corrigendum to "Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis" [Transfus Med Rev 32/2 (2018) 77-88].

    24. McQuilten ZK, French CJ, Nichol A, Higgins A, Cooper DJ. Transfus Med Rev. 2020 Apr 12:S0887-7963(20)30017-1. doi: 10.1016/j.tmrv.2020.03.002. Online ahead of print. PMID: 32295729

  • 2019

    1. The effect of a low-dose naloxone infusion on the incidence of respiratory depression after intrathecal morphine administration for major open hepatobiliary surgery: a randomised controlled trial. Cosgrave D, Vencken S, Galligan M, McGuinness S, Soukhin E, McMullan V, Hussain R, Conlon N, Doran P, Nichol A. Anaesthesia. 2019 Dec 2. doi: 10.1111/anae.14931. [Epub ahead of print]PMID: 31792949
    2. O2, do we know what to do? Young PJ, Bagshaw SM, Bailey M, Bellomo R, Mackle D, Pilcher D, Landoni G, Nichol A, Martin D. Crit Care Resusc. 2019 Dec;21(4):230-
    32. PMID: 31778627
    3. What the public think about participation in medical research during an
    influenza pandemic: an international cross-sectional survey. N. Gobat, C.C. Butler, J. Mollison, N.A. Francis, M. Gal, V. Harris, S.A.R. Webb, J.-P. Byrne, A. Watkins, P. Sukumar, K. Hood, A. Nichol. Public Health. 2019 Sep 23;177:80-94. doi: 10.1016/j.puhe.2019.07.005. PMID: 31557667
    4. Statistical analysis plan for the Standard versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. STARRT-AKI Investigators. Crit Care Resusc. 2019 Sep;21(3):162-170. PMID: 31462203.
    5. Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): A randomized clinical trial-Rationale and design.
    Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Bělohlávek J, Callaway C, Cariou A, Eastwood G, Erlinge D, Hovdenes J, Joannidis M, Kirkegaard H, Kuiper M, Levin H, Morgan MPG, Nichol AD, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Storm C, Taccone F, Ullén S, Wise MP, Young P, Friberg H, Nielsen N. Am Heart J. 2019 Jun 26;217:23-31. doi: 10.1016/j.ahj.2019.06.012. [Epub ahead of print] PMID: 31473324
    6. Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter, Randomized, Controlled Trial. Hodgson CL, Cooper DJ, Arabi Y, King V, Bersten A, Bihari S, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Paul E, Tuxen D, Vallance S, Young M, Nichol A; PHARLAP Study Investigators and the ANZICS Clinical Trials Group. Am J Respir Crit Care Med. 2019 Jul 29. doi: 10.1164/rccm.201901-0109OC. [Epub ahead of print] PMID: 31356105
    7. STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury: Study Protocol for a Multi-National, Multi-Center, Randomized Controlled Trial. STARRT-AKI Investigators. Can J Kidney Health Dis. 2019 Jun 10;6:2054358119852937. doi: 10.1177/2054358119852937. PMID: 31218013; PMCID: PMC6558541.
    8. Biomarker Predictors of Adverse Acute Kidney Injury Outcomes in Critically Ill Patients: The Dublin Acute Biomarker Group Evaluation Study. McMahon BA, Galligan M, Redahan L, Martin T, Meaney E, Cotter EJ, Murphy N, Hannon C, Doran P, Marsh B, Nichol A, Murray PT. Am J Nephrol. 2019 Jun 14:1-10. doi: 10.1159/000500231. PMID: 31203271
    9. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V, Bellani G, Griffin MD, Ranieri M, Laffey JG; ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators. Crit Care Med. 2019 Sep;47(9):1216-1225. doi: 10.1097/CCM.0000000000003832. PMID: 31162201
    10. Advancing preparedness for clinical research during infectious disease epidemics. Gobat N, Amuasi J, Yazdanpanah Y, Sigfid L, Davies H, Byrne JP, Carson G, Butler C, Nichol A, Goossens H. ERJ Open Res. 2019 May 20;5(2). pii: 00227- 2018. doi: 10.1183/23120541.00227-2018. eCollection 2019 Apr. Erratum in: ERJ Open Res. 2019 Jul 29;5(3):. PMID: 31123684
    11. Early Sedation with Dexmedetomidine in Critically Ill Patients.
    Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Bin Kadiman S, McArthur CJ, Murray L, Reade MC, Seppelt IM, Takala J, Wise MP, Webb SA; ANZICS Clinical Trials Group and the SPICE III Investigators. N Engl J Med. 2019 Jun 27;380(26):2506-2517. doi: 10.1056/NEJMoa1904710. Epub 2019 May 19. PMID:
    31112380
    12. Prophylactic Hypothermia for Severe Traumatic Brain Injury-Reply. Cooper DJ, Nichol AD, McArthur C. JAMA. 2019 May 7;321(17):1726. doi: 10.1001/jama.2019.1538. PMID: 31063568
    13. Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion Versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Clinical Trial. Irving A, Higgins A, Ady B, Bellomo R, Cooper DJ, French C, Gantner D, Harris A, Irving DO, Murray L, Nichol A, Petrie D, McQuilten ZK; Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group. Crit Care Med. 2019 Jul;47(7):e572-e579. doi: 10.1097/CCM.0000000000003781. PMID: 31008734
    14. Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long- Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial. Higgins AM, Peake SL, Bellomo R, Cooper DJ, Delaney A, Harris AH, Howe BD, Nichol AD, Webb SA, Williams PJ; Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group. Crit Care Med. 2019 Jun;47(6):765-773. doi: 10.1097/CCM.0000000000003762. PMID: 30985391
    15. Cost-Effectiveness of Erythropoietin in Traumatic Brain Injury: A Multinational Trial-Based Economic Analysis. Knott RJ, Harris A, Higgins
    A, Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars MB, Vallance S, Varma D, Wills J, Bellomo R. J Neurotrauma. 2019 May 23. doi: 10.1089/neu.2018.6229. PMID: 30907230
    16. Reported practice of temperature adjustment (α-stat v pH-stat) for arterial blood gases measurement among investigators from two major cardiac arrest trials. Eastwood GM, Nielsen N, Nichol AD, Skrifvars MB, French C, Bellomo
    R. Crit Care Resusc. 2019 Mar;21(1):69-71. PMID: 30857515
    17. Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group. Anesthesiology. 2019 Feb;130(2):263-283. doi: 10.1097/ALN.0000000000002508. PMID: 30499850
    18. Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study. van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; Large observational study to UNderstand the Global impact of Severe Acute respiratory Failure (LUNG SAFE) Investigators. Crit Care Med. 2019 Feb;47(2):229-238. doi: 10.1097/CCM.0000000000003519. PMID:
    30379668.
    23. Priority Needs for Conducting Pandemic-relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician- researchers. Gal M, Gobat N, Francis NA, Hood K, Butler CC, Bielicki J, Fraaij PL, Sharland M, Jarvis J, van Rossum AMC, Heikkinen T, Martinon-Torres F, Herberg J, Watkins A, Webb SAR, Moore R, Sukumar P, Nichol A. Pediatr Infect Dis J. 2019 May;38(5):e82-e86. doi: 10.1097/INF.0000000000002204. PMID:30256315

  • 2018

    1. Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an
    analysis of the LUNG SAFE database. Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group. Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y. PMID: 30367670

    2. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group. JAMA. 2018 Dec 4;320(21):2211-2220. doi: 10.1001/jama.2018.17075. PMID: 30357266

    3. Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial. Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators. JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283. PMID: 30357272

    4. Inflammation, immunity and allergy. Stewart D, Nichol A. Anaesthesia and Intensive Care Medicine. 2018 Oct;19(10):534-539.

    5. A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.
    Young PJ, Bagshaw SM, Forbes A, Nichol A, Wright SE, Bellomo R, Bailey MJ, Beasley RW, Eastwood GM, Festa M, Gattas D, van Haren F, Litton E, Mouncey PR, Navarra L, Pilcher D, Mackle DM, McArthur CJ, McGuinness SP, Saxena MK, Webb S, Rowan KM; Australian and New Zealand Intensive Care Society Clinical Trials Group on behalf of the PEPTIC investigators. Crit Care Resusc. 2018 Sep;20(3):182-
    189. PMID: 30153780

    6. Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial.
    Skrifvars MB, Moore E, Mårtensson J, Bailey M, French C, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-
    TBI Investigators and the ANZICS Clinical Trials Group. Acta Anaesthesiol Scand. 2019 Feb;63(2):200-207. doi: 10.1111/aas.13244. Epub 2018 Aug 21. PMID:
    30132785

    7. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries.
    Abe T, Madotto F, Pham T, Nagata I, Uchida M, Tamiya N, Kurahashi K, Bellani G, Laffey JG; LUNG-SAFE Investigators and the ESICM Trials Group. Crit Care. 2018 Aug 17;22(1):195. doi: 10.1186/s13054-018-2126-6. PMID: 30115127

    8. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group. Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2. PMID: 30078618

    9. Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial.
    Salter R, Bailey M, Bellomo R, Eastwood G, Goodwin A, Nielsen N, Pilcher D, Nichol A, Saxena M, Shehabi Y, Young P; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE). Crit Care Med. 2018 Nov;46(11):1722-1730. doi: 10.1097/CCM.0000000000003339. PMID: 30063490

    10. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group. Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9. Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9. PMID: 29895331

    11. Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome.
    Hodgson C, Cooper DJ, Arabi Y, Bennett V, Bersten A, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Tuxen D, Vallance S, Young M, Nichol AD; PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Crit Care Resusc. 2018 Jun;20(2):139-149.

    12. The undiscovered country: therapeutic targeting of carbon dioxide levels in critically ill patients. Nichol AD. Crit Care Resusc. 2018 Jun;20(2):81-
    82. No abstract available. PMID: 29852844.

    13. Pathophysiology of severe traumatic brain injury overview. O'leary RA, Nichol AD. J Neurosurg Sci. 2018 May 22. doi: 10.23736/S0390- 5616.18.04501-0. [Epub ahead of print] PMID: 29790727.

    14. Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled
    Trial.
    Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group.
    Trials. 2018 Apr 27;19(1):259. doi: 10.1186/s13063-018-2610-y. PMID: 29703266.

    15. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group.
    Intensive Care Med. 2018 May;44(5):564-577. doi: 10.1007/s00134-018-5152-6. Epub 2018 Apr 9. PMID: 29632996.
    16. Acute pancreatitis: an intensive care perspective. Flood L, Nichol A.
    Anaesthesia and Intensive Care Medicine. 2018 March;19(3):87-92.

    17. Acute kidney injury and the critically ill. Flood L, Nichol A. Anaesthesia and Intensive Care Medicine. 2018 March;19(3):87-92

    18. Bending the pandemic curve: Improving decision making with clinical research. Webb SA and Nichol AD, Critical Care medicine 2018 Mar;46(3):442-
    446. doi: 10.1097/CCM.0000000000002912. PMID: 29474325.

  • 2017

    1. Cause and timing of death and sub-group differential effects of erythropoietin in the EPO-TBI study. Skrifvars MB, French C, Bailey M, Presneill J, Nichol A, Little L, Duranteau J, Huet O, Haddad S, ArabiY, McArthur C, Cooper DJ, Bellomo R.J Neurotrauma. 2017 Oct 12. doi: 10.1089/neu.2017.5135. [Epub ahead of print] PMID:29020866.

    2. The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial. Cosgrave D, Galligan M, Soukhin E, McMullan V, McGuinness S, Puttappa A, Conlon N, Boylan J, Hussain R, Doran P, Nichol A. Trials. 2017 Dec 29;18(1):633. doi: 10.1186/s13063-017-2370-0. PMID: 29284510.


    3. Potential Impact of the 2016 Consensus Definitions of Sepsis and Septic Shock on Future Sepsis Research. Peake SL, Delaney A, Bailey M, Bellomo R; ARISE Investigators. Ann Emerg Med. 2017 Oct;70(4):553-561

    4. Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries.Gobat NH, Gal M, Butler CC, Webb SAR, Francis NA, Stanton H, Anthierens S, Bastiaens H, Godycki-Ćwirko M, Kowalczyk A, Pons-Vigués M, Pujol- Ribera E, Berenguera A, Watkins A, Sukumar P, Moore RG, Hood K, Nichol A. Health Expect. 2017 Sep 27. doi: 10.1111/hex.12634. [Epub ahead of print] PMID:28960624

    5. Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults.Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.N Engl J Med. 2017 Sep 27. doi: 10.1056/NEJMoa1707572. [Epub ahead of print] PMID:28952891 Erratum: Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults. N Engl J Med. 2019 Aug 29;381(9):890. doi: 10.1056/NEJMx180024. Epub 2019 Aug 1.

    6. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F, Ranieri M, Rubenfeld G, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Lancet Respir Med. 2017 Aug;5(8):627-638. doi: 10.1016/S2213-2600(17)30213-
    8. Epub 2017 Jun 15. PMID: 28624388

    7. Targeted therapeutic mild hypercapnia after cardiac arrest. Eastwood GM, Nichol A, Wise MP.Crit Care. 2017 Jul 31;21(1):196. doi: 10.1186/s13054-017- 1770-6. No abstract available.PMID:28756765

    8. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta- Analysis. PRISM Investigators, Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. N Engl J Med. 2017 Jun 8;376(23):2223-2234.

    9. Co-enrolment for the TAME and TTM-2 trials: the cerebral option. Parke RL, McGuinness S, Eastwood GM, Nichol A, Nielsen N, Dankiewicz J, Bellomo R.Crit Care Resusc. 2017 Jun;19(2):99-100. No abstract available.PMID:28651502

    10. Erythropoietin in patients with traumatic brain injury and extracranial injury-A post hoc analysis of the erythropoietin traumatic brain injury trial. Skrifvars MB, Bailey M, French C, Presneill J, Nichol A, Little L,
    Duranteau J, Huet O, Haddad S, Arabi Y, McArthur C, Cooper DJ, Bellomo R; EPO-TBI investigators and the ANZICS Clinical Trials Group.J Trauma Acute Care Surg. 2017 Sep;83(3):449-456. PMID:28590358

    11. Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research. Gobat NH, Butler CC, Webb SAR, Nichol A; PREPARE-EARL Study Team..J Crit Care. 2017 Mar 27. pii: S0883-9441(17)30363-
    5. doi: 10.1016/j.jcrc.2017.03.019. [Epub ahead of print] No abstract available.PMID: 28438372

    12. Shock: causes, initial assessment and investigations Teirney P, Ahmed B,
    Nichol A. Anaesthesia and Intensive Care Medicine 18(3):118-121 01 Mar 2017


    13. Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post- hoc Dose-effect Analysis.Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, Bellomo R; EPO-TBI Investigators; and the ANZICS Clinical Trials Group. Ann Surg. 2017 Feb 1. doi: 10.1097/SLA.0000000000002142. [Epub ahead of print]
    14. Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study. Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, Larsson A, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators.; ESICM Trials Group..Am J Respir Crit Care Med. 2017 Jan 1;195(1):67-77. doi: 10.1164/rccm.201606-1306OC.PMID: 27753501

  • 2016

    1. Craniectomy for Traumatic Intracranial Hypertension.Cooper DJ,
    Nichol A, Hodgson C. N Engl J Med. 2016 Dec 15;375(24):2402. PMID: 28032966

    2. Venous thromboembolic events in critically ill traumatic brain injury patients. Markus B Skrifvars, MD, PhD, EDIC, FCICM; Michael Bailey; Jeffrey Preisnell; Craig French, FCICM; Alistair Nichol; Lorraine Little; Jacques Duranteau; Olivier Huet; Samir Haddad; Yaseen Arabi; Colin McArthur; Douglas J Cooper; Rinaldo Bellomo. Intensive Care Medicine(In press)

    3. Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group. Intensive Care Med. 2016 Dec;42(12):1865-1876. doi: 10.1007/s00134-016-4571-5. Epub 2016 Oct 18. PMID: 27757516 Erratum in Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. [Intensive Care Med. 2018]

    4. Public attitudes towards research participation during an infectious disease pandemic: a qualitative study across four European countries. Gobat
    NH, GAL M, Butler CC, Francis NA, Anthierens S, Bastiaen H, Godycki-cwirko M, Kowalczyk A, Pons-Vigues M, Pujol-Ribera E, Berenguera A, Stanton H, Watkins A, Hood K, Moore R, Sukumar P, Webb SA, , Nichol A. The Lancet. 2016 Nov 1;388:51

    5. Who Says There Is No "I" in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S; International Forum for Acute Care Trialists.Am J Respir Crit Care Med. 2016 Oct 1;194(7):911-912. PMID:27689708

    6. Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective. Glassford NJ, Mårtensson J, Eastwood GM, Jones SL, Tanaka A, Wilkman E, Bailey M, Bellomo R; Arabi Y, Bagshaw SM, Bannard-Smith J, Bin D, Dubin A, Duranteau J, Echeverri J, Hoste E, Joannidis M, Kashani K, Kellum J, Kulkarni AP, Landoni G, Candal CL, Matejovic M, Yunos NM, Nichol A.. Et alGLobal OBservational Evaluations in the ICU (GLOBE-ICU) investigators..J Crit Care. 2016 Oct;35:126-32. doi: 10.1016/j.jcrc.2016.05.017.PMID:27481747

    7. The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study. Sakr Y, Ferrer R, Reinhart K, Beale R, Rhodes A, Moreno R, Timsit JF, Brochard L, Thompson BT, Rezende E, Chiche JD; IC-GLOSSARI Investigators; ESICM Trials Group. Intensive Care Med. 2016 May;42(5):817-828. doi: 10.1007/s00134-015- 4206-2. Epub 2016 Feb 15. Erratum in: Intensive Care Med. 2016 May;42(5):953. Intensive Care Med. 2018 Jan;44(1):144-152.
    PMID: 26880091

    8. Erythropoiesis-stimulating Agents in Critically Ill Trauma Patients: A Systematic Review and Meta-analysis. French CJ, Glassford NJ, Gantner D, Higgins AM, Cooper DJ, Nichol A, Skrifvars MB, Imberger G, Presneill J, Bailey M, Bellomo R.Ann Surg. 2016 Apr 8. PMID:27070933

    9. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.Cooper DJ, Nichol A, Presneill J.N Engl J Med. 2016 Apr 7;374(14):1384. doi: 10.1056/NEJMc1600339#SA3. PMID:27050215

    10. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum in: JAMA. 2016 Jul
    19;316(3):350. JAMA. 2016 Jul 19;316(3):350.PMID: 26903337

    11. Status epilepticus: An intensive care medicine problem. O'Connor C, Hanna J, Nichol A Anaesthesia and Intensive Care Medicine 17(1):27-30 01 Jan 2016

  • 2015

    1. Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research
      preparedness. Gobat NH, Gal M, Francis NA, Hood K, Watkins A, Turner J, Moore R, Webb SA, Butler CC, Nichol A. Trials. 2015 Dec 29;16:591. doi: 10.1186/s13063- 015-1110-6. PMID:26715077
    2. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.*Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars M, Vallance S, Varma D, Wills J, Bellomo R; EPO-TBI Investigators.; ANZICS Clinical Trials Group..Lancet. 2015 Dec 19;386(10012):2499-506. doi: 10.1016/S0140-6736(15)00386-4.PMID:26452709
    3. Inflammation, immunity and allergy. O'Connor C, Nichol A. Anaesthesia and Intensive Care Medicine 16(7):328-333 01 Jul 2015
    4. Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury. * Nichol A, Gantner D, Presneill J, Murray L, Trapani T, Bernard S, Cameron P, Capellier G, Forbes A, McArthur C, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Walker T, Webb S, Cooper DJ.Crit Care Resusc. 2015 Jun;17(2):92-100.  doi: https://doi.org/10.1016/S1441-2772(23)01066-9PMID:26017126
    5. Acute pancreatitis: An intensive care perspective. Dooley N, Hew S, Nichol A. Anaesthesia & Intensive Care Medicine. 2015 Apr 1;16(4):191-6  10.1016/j.mpaic.2015.01.017
    6. Acute kidney injury and the critically ill. Ahmed B, Hanna J, Nichol A. Anaesthesia and Intensive Care Medicine 16(4):186-190 01 Apr 2015  doi: 10.1016/j.mpaic.2015.01.016
    7. Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial.*Nichol A, French C, Little L, Presneill J, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Trials. 2015 Feb 8;16:39. doi: 10.1186/s13063-014-0528- 6.PMID:25884605

  • 2014

    1. Shock: causes, initial assessment and investigations. Nichol A and Ahmed B. Anaesthesia & Intensive Care Medicine. 2014 Feb 1;15(2):64-7 doi: 10.1016/j.mpaic.2013.12.008
    2. Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury. Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators.; ANZICS Clinical Trials Group..Trials. 2014 Dec 20;15:501. doi: 10.1186/1745-6215-15-501.PMID:25528574
    3. A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan. Kaukonen KM, Bailey M, Ady B, Aubron C, French C, Gantner D, Irving D, Murray L, Nichol A, Pettilä V, McQuilten Z, Cooper DJ.Crit Care Resusc. 2014 Dec;16(4):255-61  PMID:25437218
    4. Erythropoietin for traumatic brain injury.*Nichol A, Little L, French C.JAMA. 2014 Nov 12;312(18):1928-9 doi: 10.1001/jama.2014.12738  PMID:25387193
    5. Simvastatin in the acute respiratory distress syndrome. McAuley DF, Laffey JG, O'Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C; HARP-2 Investigators; Irish Critical Care Trials Group. NEJM. 2014 Oct 30;371(18):1695-703. doi: 10.1056/NEJMoa1403285. Epub 2014 Sep 30. Erratum in: N Engl J Med. 2016 Nov 17;375(20):2010 PMID: 25268516
    6. Goal-directed resuscitation for patients with early septic shock. ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1. PMID: 25272316
    7. Open source clinical science for emerging infections.Dunning JW, Merson L, Rohde GG, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere KS, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien TT, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T; ISARIC Working Group 3, ISARIC Council., Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJ, Farrar J, Carson G, Baillie JK.Lancet Infect Dis. 2014 Jan;14(1):8-9  doi: 10.1016/S1473-3099(13)70327-X. PMID:24355025